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NOUVEAU COMPOSÉ DE PIPÉRIDINE OU SEL DE CELUI-CI
专利权人:
Taiho Pharmaceutical Co.; Ltd.
发明人:
申请号:
EP13755229.5
公开号:
EP2821406A1
申请日:
2013.02.27
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
A novel compound which has an excellent aurora A-selective inhibitory action and is useful as an orally administrable anticancer agent is provided. Also, a novel agent for potentiation of anti-tumor effect of microtubule agonists, which include a taxane anticancer agent, and a combination therapy are provided. A piperidine compound represented by a general formula (I) or a salt thereof:wherein, R1 represents a carboxyl group, -C(=O)NR5R6, or an oxadiazolyl group optionally having a C1-C6 alkyl group or a trifluoromethyl group as a substituent;R2 represents a halogen atom or a C1-C6 alkoxy group;R3 represents a phenyl group optionally having 1 to 3 same or different group(s) selected from a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group, and a trifluoromethyl group as a substituent;R4 represents a hydrogen atom or a C1-C6 alkyl group; andR5 and R6 are the same or different and each represent a hydrogen atom, a C1-C6 alkyl group, or a C3-C6 cycloalkyl group, or R5 and R6 optionally form a 3 to 6-membered nitrogen-containing saturated heterocyclic group together with a nitrogen atom to which R5 and R6 are bound, are provided.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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