The USA; as represented by the Secretary; Department of Health and Human Services
发明人:
Dean HAMER
申请号：
US13735638
公开号：
US20130209407A1
申请日:
2013.01.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates, e.g., to a commensal bacterium which can colonize the genitourinary and/or gastrointestinal mucosa, and which, under suitable conditions, secretes a heterologous antimicrobial polypeptide, wherein the secreted antimicrobial polypeptide is effective to inhibit infectivity by, or a pathogenic activity of, a pathogen. In a most preferred embodiment, the antimicrobial polypeptide inhibits HIV infection (e.g., fusion) and/or pathogenesis. Also described are preventive or therapeutic compositions comprising the commensal bacteria, and methods to inhibit infectivity and/or pathogenesis, using the bacteria.
