The present invention relates to an oxazine derivative BACE-1 inhibitor and pharmaceutical compositions comprising such oxazine derivative for use in the prevention of Alzheimer’s disease in a patient at risk of developing clinical symptoms of Alzheimer’s disease, and in particular, wherein the patient at risk of developing clinical symptoms of Alzheimer’s disease carries one or two copies of the ApoE4 allele.本發明係關於㗁𠯤；衍生物BACE-1抑制劑及包含該㗁𠯤；衍生物之醫藥組合物，其用於預防具有發展阿茲海默症(Alzheimer’s disease)臨床症狀風險之病患之阿茲海默症，且具體而言，其中具有發展阿茲海默症臨床症狀風險之該病患攜帶ApoE4等位基因之一或兩個拷貝。
