A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, FLUTICASONE PROPIONATE, OXICONAZOLE NITRATE AND A PROCESS TO MAKE IT
The present invention is directed to a medicinal composition for treating skin inflammations, fungal/bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises Chitosan. Fluticasone Propionate, Oxiconazole Nitrate and Fusidic acid. The invention also 10 discloses a process to make the medicinal cream containing Fusidic Acid which is formed in situ from Sodium Fusidate as the starting raw material, wherein Sodium Fusidate is converted into Fusidic Acid under oxygen-free environment created using inert gas, preferably nitrogen, and Chitosan. The cream produced by the process of the present invention has greater shelf-life stability and the finer 15 particle size of the API than the conventional creams containing Fusidic Acid. The cream produced by the process of the present invention contains Fusidic Acid as the API that has been formed in situ from Sodium Fusidate, Fluticasone Propionate & Oxiconazole Nitrate in a cream base comprising a preservative, an acid, a co-solvent, an emulsifier and a waxy material along with water, preferably 20 purified water.La présente invention concerne une composition médicinale destinée au traitement dinflammations cutanées, dinfections cutanées fongiques/bactériennes et de lésions associées, ainsi que dautres lésions cutanées comprenant celles provoquées par des brûlures. Ladite crème entraîne également un rajeunissement cutané, par un processus dépithélisation. Ladite crème comprend du chitosane, du propionate de fluticasone, du nitrate doxiconazole et de lacide fusidique. Linvention concerne également un procédé de fabrication de ladite crème médicinale contenant de lacide fusidique formé in situ à partir de fusidate de sodium en tant que produit de départ, ledit fusidate de sodium étant transformé en acide fusidique dans un milieu exempt doxygène, créé avec un gaz inerte, de préférence de la
