The present invention provides a compound represented by the formula: wherein R<；SUP>；1 <；/SUP>；is a C<；SUB>；1-4<；/SUB>；alkyl； R<；SUP>；2 <；/SUP>；is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1') a halogen, (2') a hydroxy group, (3') a C<；SUB>；1-4<；/SUB>；alkyl and (4') a C<；SUB>；1-4<；/SUB>；alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1') a halogen, (2') a C<；SUB>；1-4<；/SUB>；alkoxy-C<；SUB>；1-4<；/SUB>；alkyl, (3') a mono-C<；SUB>；1-4<；/SUB>；alkyl-carbamoyl-C<；SUB>；1-4<；/SUB>；alkyl, (4') a C<；SUB>；1-4<；/SUB>；alkoxy and (5') a mono-C<；SUB>；1-4<；/SUB>；alkylcarbamoyl-C<；SUB>；1-4<；/SUB>；alkoxy, or the like； R<；SUP>；3 <；/SUP>；is a C<；SUB>；1-4<；/SUB>；alkyl； R<；SUP>；4 <；/SUP>；is a C<；SUB>；1-4<；/SUB>；alkoxy, or the like； n is an integer of 1 to 4； or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity.
