Jaclyn R. Patterson;Krista B. Goodman;Hilary Schenck Eidam;Mui Cheung;Carl Brooks;Marlys Hammond;Mark A. Hilfiker;Tram H. Hoang;Guosen Ye;Patrick Stoy
发明人:
Carl Brooks,Mui Cheung,Hilary Schenck Eidam,Krista B. Goodman,Marlys Hammond,Mark A. Hilfiker,Tram H. Hoang,Jaclyn R. Patterson,Patrick Stoy,Guosen Ye
申请号：
US14125378
公开号：
US09187464B2
申请日:
2012.06.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
