The present invention relates to compounds compositions and methods for the study diagnosis and treatment of traits diseases and conditions that respond to the modulation of HBV gene expression and/or activity and/or modulate a HBV gene expression pathway. Specifically the invention relates to double stranded nucleic acid molecules including small nucleic acid molecules such as short interfering nucleic acid (siNA) short interfering RNA (siRNA) double stranded RNA (dsRNA) micro RNA (miRNA) and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against HBV gene expression.
