Combination therapy regimens including liposomal irinotecan, oxaliplatin and 5-fluorouracil are useful in the treatment of pancreatic cancer, including treatment of patients diagnosed with previously untreated metastatic adenocarcinoma of the pancreas. The combination therapy can include the administration of liposomal irinotecan, oxaliplatin, leucovorin and 5-fluorouracil once every two weeks.本發明係關於包括微脂伊立替康(irinotecan)、奧沙利鉑(oxaliplatin)及5-氟尿嘧啶之組合療法方案,其可用於治療胰臟癌,包括治療經診斷患有先前未治療之胰臟之轉移性腺癌之患者。該組合療法可包括每兩週一次投與微脂伊立替康、奧沙利鉑、若克瘤(leucovorin)及5-氟尿嘧啶。