Muhammad Iqbal Choudhary,Saima Rasheed,Nessar Ahmed,Khalid M. Khan,Momin Khan,Atta-ur Rahman,Atia-tul- Wahab
申请号：
US13954648
公开号：
US20150038543A1
申请日:
2013.07.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention provides a series of new oxindole derivatives 1-21, evaluated for their antiglycation potential by using in vitro BSA-MG glycation model. These derivatives showed a varying degree of antiglycation activity with IC50 values ranging between 150-856 μM. Compound 14 (IC50=150.4±2.5 μM) was found to be the most potent among all derivatives, even better than the standard inhibitor i.e. rutin (IC50=294.5±1.50 followed by compounds 13 and 8 with IC50 value of 194.40±2.5 and 211.41±4.1 μM, respectively.
