NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY;EVEC INCORPORATED
发明人:
TAKADA KENZO,TORASHIMA TAKASHI,NISHIBORI MASAHIRO
申请号：
EP13872417
公开号：
EP2949675A4
申请日:
2013.12.06
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides a humanized anti-HMGB1 antibody which specifically binds to a sequence consisting of the C-terminal 8 amino acid residues (EEEDDDDE) of HMGB1 protein and is effective for treatment or prevention of various inflammatory diseases related to this protein, as well as an antigen-binding fragment thereof. The present invention also provides a pharmaceutical composition comprising such an antibody or antigen-binding fragment thereof.
