The present invention relates to antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of eliciting certain biological responses using the antibodies. Methods of identifying anti-VISTA antibodies capable of eliciting certain biological responses are also included.本發明係關於結合於T細胞活化之V域Ig抑制因子(VISTA)之抗體及片段,及使用該等抗體引發某些生物反應之方法。亦包括鑑定能夠引發某些生物反應之抗VISTA抗體之方法。