Dae Jin Kim;Min Young Kim;Sung Youb Jung;Jin Sun Kim;Sung Hee Hong;Se Chang Kwon
发明人:
Dae Jin Kim,Min Young Kim,Jin Sun Kim,Sung Hee Hong,Sung Youb Jung,Se Chang Kwon
申请号：
US13638821
公开号：
US20130028867A1
申请日:
2011.04.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a long-acting interferon beta formulation having improved in vivo duration and stability, comprising an interferon beta conjugate that is prepared by covalently linking interferon beta with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting interferon beta formulation of the present invention maintains in vivo activity of interferon beta at a relatively high level and remarkably increases the serum half-life thereof, thereby being used for various diseases, for which interferon is efficacious.
