Татьяна Николаевна,Екатерина Фёдоровна,Екатерина Юрьевна,Игорь Геннадьевич
申请号：
EA201890607
公开号：
EA201890607A1
申请日:
2016.10.21
申请国别(地区):
EA
年份:
2018
代理人:
摘要：
in one aspect of the invention a method of targeted (\u0442\u0430\u0440\u0433\u0435\u0442\u043d\u043e\u0439) delivery \u043e\u0434\u043d\u043e\u0432\u0430\u043b\u0435\u043d\u0442\u043d\u043e\u0433\u043e thallium salts.including the preparation of \u0432\u0438\u0440\u0438\u043e\u043d\u043e\u0432 \u0444\u0430\u0433\u0430 MS2 or \u0432\u0438\u0440\u0443\u0441\u043f\u043e\u0434\u043e\u0431\u043d\u043e\u0439 particles with subsequent modification of superficiality cyclical \u043b\u0438\u0433\u0430\u043d\u0434\u043e\u043c filled \u043e\u0434\u043d\u043e\u0432\u0430\u043b\u0435\u043d \u0442\u043d\u044b\u043c\u0438 thallium salts,that the way of cooking does not allow \"\u0432\u044b\u0442\u0435\u043a\u0430\u043d\u0438\u044f\" ion metal \u0432\u0438\u0440\u0438\u043e\u043d\u043e\u0432 before their physical or biochemical degradation.in related aspects of the invention a method of targeted delivery of salts (\u0442\u0430\u0440\u0433\u0435\u0442\u043d\u043e\u0439) \u043e\u0434\u043d\u043e\u0432\u0430\u043b\u0435\u043d\u0442\u043d\u043e\u0433\u043e thallium isotope 201Tl.in the preferred form \u043b\u0438\u0433\u0430\u043d\u0434\u043e\u043c is a cyclic polypeptide capable of interacting with the receptors of cells and in the most preferred waria soa no \u043b\u0438\u0433\u0430\u043d\u0434\u043e\u043c serves iRGD.ligand can be chemically \u043a\u043e\u043d\u044a\u044e\u0433\u0438\u0440\u043e\u0432\u0430\u043d for education \u043a\u043e\u0432\u0430\u043b\u0435\u043d\u0442\u043d\u043e\u0433\u043e adherence or connected by a merger with the sequence of the gene and protein.in preferred versions of thallium salt \u043e\u0434\u043d\u043e\u0432\u0430\u043b\u0435\u043d\u0442\u043d\u043e\u0433\u043e choose group \u0433\u0430\u043b\u043e\u0438\u0434\u043d\u044b\u0445 salts, acetate, nitrate, sulfate, carbonate.in the present invention the substance, where \u0432\u0438\u0440\u0438\u043e\u043d\u044b \u0444\u0430\u0433\u0430 MS2 or \u0432\u0438\u0440\u0443\u0441\u043f\u043e\u0434\u043e\u043
