Oligo-nucleotides that stimulate the proliferation of stem cells or mesenchymal stem cells and their uses. Oligonucleotides are presented that have the ability to stimulate, to a large extent, the proliferation of multipotent mesenchymal stem cells, both "in vitro" and "in vivo", of animals and even humans. These oligonucleotides can be used in a wide variety of clinical procedures, such as (1) in the regeneration of damaged mesenchymal tissues through acute injury, abnormal gene expression or disease acquired by inoculation of ODN (oligodeoxyribonucleotides)； (2) for treating a guest with damaged mesenchymal tissue by removing small portions of the bone marrow, isolating the mesenchymal stem cells and treating the damaged tissue with CSM cells expanded in culture by incubating one or more ODN of this invention, combined with an appropriate biocompatible carrier to transport MSC to the point of the damaged body； (3) for "in vitro" production of various mesenchymal tissues by differentiation conducted from CSM cells expanded in culture by incubation with one or more ODN of the present invention and transformed by genetic engineering procedures to express a protein capable of replacing the genetic defect.Oligo-nucleótidos estimuladores da proliferação de células-mãe ou células tronco mesenquimatosas e seus usos. São apresentados os oligonucleotídeos que possuem a capacidade de estimular, em grande medida, a proliferação de células tronco mesenquimatosas multipotentes, tanto "in vitro" quanto "in vivo", de animais e inclusive de humanos. Esses oligonucleotídeos podem ser utilizados em uma ampla variedade de procedimentos clínicos, tais como (1) na regeneração de tecidos mesenquimatosos danificados através de uma lesão aguda, expressão genética anormal ou doença adquirida por inoculação dos ODN (oligodeoxyribonucleotides)； (2) para tratamento de um hóspede com tecido mesenquimatoso danificado por meio da remoção de pequenas porções da medula óssea,isolamento das células
