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Novel prenylarene compounds and uses thereof
专利权人:
国立大学法人大阪大学
发明人:
小林 資正,古徳 直之,荒井 雅吉,河内 崇志
申请号:
JP2012513828
公开号:
JP5721082B2
申请日:
2011.05.06
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
A compound represented by the general formula (C): (wherein R 101 represents a substituted or unsubstituted aromatic heterocyclic group, R 102 , R 103 , R 104 and R 105 may be the same or different, and each represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a haloalkyl group having 1 to 3 carbon atoms, and R 106 represents a hydrogen atom, or a saturated or unsaturated hydrocarbon group which is a straight or branched chain having 1 to 12 carbon atoms, but excluded is the case where R 101 is a 3-furyl group, R 102 , R 103 , R 104 and R 105 are all methyl groups, and R 106 is a methyl group, a 4-methyl-3-pentenyl group or a 4,8-dimethyl-3,7-nonadienyl group); or a pharmaceutically acceptable salt thereof has selective inhibitory activity on hypoxic cell growth in a broad range of the concentration and therefore is useful as an active ingredient of a medicament for cancer prevention or treatment.
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