Peter Brams;Michelle Kuhne;Josephine M. Cardarelli;Dawn M. Tanamachi;Alan J. Korman
发明人:
Michelle Kuhne,Peter Brams,Dawn M. Tanamachi,Alan J. Korman,Josephine M. Cardarelli
申请号：
US12444130
公开号：
US08450464B2
申请日:
2007.10.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.
