The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to certain di-isopropyl-phosphinoyl-alkanes as described herein, DIPA-1-5, DIPA-1-6, DIPA-1-7, DIPA-1-8, and DIPA-1-9, collectively referred to herein as “DIPA compounds”, that are useful, for example, in the treatment of disorders (e.g., diseases) including: sensory discomfort (e.g., caused by irritation, itch, or pain); a skin dysesthesia; dermatitis; ocular pain and discomfort; heat discomfort; heat stress; flushing and/or night sweats (vasomotor symptoms); post-operative hypothermia; post-anaesthetic shivering; fatigue; tiredness; depression; cognitive dysfunction; and to enhance cognitive function. The applicant has found that localized delivery of DIPA compounds to the upper eyelid and/or facial skin has an alerting and enhancement effect on behavior and can be used to give a cosmetic refreshing look, to mental alertness, to reduce fatigue, and to improve work output. The present discovery also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy, in diagnosis of neuropathic pain, and in study of TRPM8 function.La présente invention concerne d'une façon générale le domaine des composés thérapeutiques. Plus précisément, la présente invention concerne certains di-isopropyl-phosphinoyl-alcanes tels que décrits dans l'invention (DIPA-1-6, DIPA-1-7, DIPA-1-8, et DIPA-1-9, collectivement désignés dans l'invention par "composés DIPA") qui sont utiles par exemple dans le traitement de troubles (p.ex, de maladies) comprenant : la gêne sensorielle (p.ex, provoquée par une irritation, des démangeaisons ou une douleur) ; une dysesthésie de la peau ; une dermatite ; un psoriasis ; une gêne oculaire ; une gêne à la chaleur, un stress thermique ; des bouffées et/ou des sueurs nocturnes (symptômes vasomoteurs) chez les femmes post-ménopausées ; une hypothermie post