The invention relates to a use of a Moutan Cortex extract for anti-inflammation by applying an effective does of the Moutan Cortex extract to LPS-induced inflammatory cells. The Moutan Cortex extract is manufactured by at least one extraction step, one filtration step and one concentration step. Accordingly, the Moutan Cortex extract can be further utilized in manufacturing food additives or pharmaceutical compositions for inhibiting inflammation.本發明係有關於牡丹皮萃取物用以抗發炎之用途,其係將一有效劑量之一牡丹皮萃取物作用至利用LPS誘導發炎之細胞,其中,牡丹皮萃取物係藉由至少一萃取步驟、一過濾步驟以及一濃縮步驟而製得;藉此,可進一步利用牡丹皮萃取物作為抑制發炎之食品添加物或醫藥組成物。