PIERRE JEAN-MARIE RABOISSON,HERMAN AUGUSTINUS DE KOCK,SANDRINE MARIE HELENE VENDEVILLE,HU LILI,WIM VAN DE VREKEN,DAVID GRAIG MC GOWAN,ABDELLAH TAHRI,DOMINIQUE LOUIS NESTOR GHISLAIN SURLERAUX,KENNETH A
申请号：
MYPI 20063671
公开号：
MY152153A
申请日:
2006.07.28
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
INHIBITORS OF HCV OF FORMULA (I) AND THE N-OXIDES, SALTS, AND STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN R1 IS ARYL OR A SATURATED, A PARTIALLY UNSATURATED OR COMPLETELY UNSATURATED 5 OR 6 MEMBERED MONOCYCLIC OR 8 TO 12 MEMBERED BICYCLIC HETEROCYCLIC RING SYSTEM CONTAINING ONE NITROGEN, AND OPTIONALLY ONE TO THREE OXYGEN, SULFUR OR NITROGEN, WHEREIN SAID RING SYSTEM MAY BE OPTIONALLY SUBSTITUTED； L IS A DIRECT BOND, -O-, -O-C1-4ALKANEDIYL-, -O-CO-, -0-C(=O)-NR5a- OR -O-C(=O)-NR5a-C1-4ALKANEDIYL-； R2 IS HYDROGEN, -OR6, -C(=O)OR6, -C(=O)R7, -C(=O)NR5aR5b, -C(=O)NHR5c, -NR5aR5b, -NHR5c, -NHSOpNR5aR5b, -NR5aSOpR8, OR -B(OR6)2: R3 AND R4 ARE HYDROGEN OR C1-6ALKYL； OR R3 AND R4 TAKEN TOGETHER MAY FORM A C3-7CYCLOALKYL RING； N IS 3, 4, 5, OR 6； P IS 1 OR 2； ARYL IS PHENYL, NAPHTHYL, INDANYL, OR 1,2,3,4-TETRAHYDRONAPHTHYL, EACH OF WHICH MAY BE OPTIONALLY SUBSTITUTED HET IS A 5 OR 6 MEMBERED SATURATED, PARTIALLY UNSATURATED OR COMPLETELY UNSATURATED HETEROCYCLIC RING CONTAINING 1 TO 4 HETEROATOMS EACH INDEPENDENTLY SELECTED FROM NITROGEN, OXYGEN AND SULFUR, BEING OPTIONALLY CONDENSED WITH A BENZENE RING, AND WHEREIN THE GROUP HET AS A WHOLE MAY BE OPTIONALLY SUBSTITUTED； PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS (I) AND PROCESSES FOR PREPARING COMPOUNDS (I). BIOAVAILABLE COMBINATIONS OF THE INHIBITORS OF HCV OF FORMULA (I) WITH RITONAVIR ARE ALSO PROVIDED.
