The present invention relates to an anti-human .alpha.9 integrin antibody.Moreparticularly, the present invention relates to: a monoclonal antibody, achimeric antibody, ahumanized antibody and a human antibody that specifically recognize human.alpha.9 integrin;a hybridoma cell that produces the monoclonal antibody; a method for producingthemonoclonal antibody; a method for producing the hybridoma cell; a therapeuticagentcomprising the anti-human .alpha.9 integrin antibody; a diagnostic agentcomprising the human.alpha.9 integrin antibody; and a method for screening for a compound thatinhibits the activityof human .alpha.9 integrin.