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N-heterocyclic carbene platinum derivatives, their preparation, and their therapeutic use
专利权人:
サノフイ;サノフイ;サントル ナシオナル ドゥ ラ ルシェルシェ シアンティフィク
发明人:
マイイエ,パトリツク,マリネツテイ,アンジエラ,スカンデル,ミリアム,マイイエ,パトリツク,マリネツテイ,アンジエラ,スカンデル,ミリアム
申请号:
JP2010549173
公开号:
JP5385923B2
申请日:
2009.03.02
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
The invention relates to the platinum N-heterocycle derivatives of general formula (I) in which-R1 and/or R2 are, independently of one another, an aryl or aralkyl group, each optionally substituted, a linear or branched C1-C6 alkyl group, a monocyclic C3-C7 cycloalkyl group or a linear or branched C2-C6 alkenyl group, or else R' is a hydrogen atom and R is a group selected from the following groups: cycloalkyl or heterocycloalkyl, which is monocyclic or bicyclic and has from 3 to 8 carbon atoms, or benzyl, which is optionally substituted, or else R and R' form, together with NH, a C3-C8 monocyclic or bicyclic heterocycloalkyl, V is a nitrogen atom or a C-R4 radical, R3 and/or R4 are hydrogen or a phenyl group or R3 and R4 may also together form a C3-C6 alkylene radical or a C3-C6 heteroalkylene radical with one or more nitrogenous heteroatoms, it being possible for the carbon atoms of the heteroalkylene radical to be modified in the form of a carbonyl radical, and X is iodine, bromine, chlorine or a nitrato (-ONO2) group.
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