This invention relates to the combination of vemurafenib and the heat shock protein 90 (HSP90) inhibitor XL888 to treat melanoma, particularly BRAF V600 mutant melanoma in patients in need of such treatment.本發明係關於維羅非尼與熱休克蛋白90(HSP90)抑制劑XL888之組合,其用於治療需要此類治療之患者的黑素瘤,尤其BRAF V600突變黑素瘤。