CARBOULEC, NICOLAS PIERRE, YVES,MERIAN, GILDAS,LABATUT, RENE,GERENTES, LIONEL
申请号：
PH12015500700
公开号：
PH12015500700A1
申请日:
2015.03.27
申请国别(地区):
PH
年份:
2015
代理人:
摘要：
The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
