#$%^&*AU2013200017A120130124.pdf#####C:\NRPortbl\DCC\FMT\4836303_I.DOC-2/01/2013 ABSTRACT The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.