It refers to the molecules connected to B7-H3 that can be combined with human and non-human B7-H3, especially the reactive molecules (such as a cynomolgus monkey) that cross B7-H3 of non-human primates. These molecules linked to B7-H3 include variable light chain domains and / or variable heavy chain domains (VHS), which have been humanized and / or dehumanized, so they show lower immunity in the management of receptors. In particular, the invention aims at bispectral, triplet or multi specification molecules from joint sign to B7-H3, including bispectral, bit, bispectral antibody and joint trivalent molecule,They include: (1) the variable domain connected to B7-H3 and (2) a domain that can connect to the top of a molecule existing on the surface of a plasma cell. It also refers to drug synthesis and methods of treating cancer and other diseases and diseases.Se refiere a moleculas de union a B7-H3 capaces de unirse a B7-H3 humanas y no-humanas, y en particular a tales moleculas que son un reactivo cruzado con B7-H3 de un primate no humano (por ejemplo, un mono cynomolgus). Dichas moleculas de union a B7-H3 comprenden Dominios de Cadena Ligera Variable y/o Cadena Pesada Variable (VH) que se han humanizado y/o deshumanizado de manera que presentan una inmunogenicidad reducida en la administracion a los sujetos receptores. La invencion particularmente se refiere a moleculas biespecificas, triespecificas o multiespecificas de union a B7 - H3, que incluyen diacuerpos biespecificos, BiTEs, anticuerpos biespecificos, moleculas de union trivalentes, etc. que comprenden: (i) tales Dominios Variables de union a B7-H3 y (ii) un dominio capaz de unirse un epitopo de una molecula presente en la superficie de una celula efectora. Tambien se refiere a composiciones farmaceuticas y a metodos en el tratamiento de cancer y otras enfermedades y padecimientos.
