Elena Valentinovna ARSHINTSEVA;Sergei Yurevich PUSHKIN
发明人:
Elena Valentinovna ARSHINTSEVA,Sergei Yurevich PUSHKIN
申请号：
US16637276
公开号：
US20200247570A1
申请日:
2018.07.12
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention relates to chemical and pharmaceutical industry, in particular to technologies of obtaining sterile drugs, drug substances and cosmetic products used in the form of solutions or emulsions, and comprising poloxamer. The thermal method for sterilizing aqueous poloxamer solutions is provided, the method including: dissolving a poloxamer in water for injection； performing the sterilizing filtration of the aqueous poloxamer solution simultaneously with filling sterile containers with the filtered poloxamer solution； sealing the containers containing the poloxamer solution； applying a thermal sterilization with steam under pressure to the containers containing the poloxamer solution, and cooling them, wherein the thermal sterilization of the containers containing the poloxamer solution with steam under pressure is performed under the pressure between 82.4 and 107.8 kPa.
