THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;THE UNIVERSITY OF BRITISH COLUMBIA
发明人:
KIZHAKKEDATHU, JAYACHANDRAN,MORRISSEY, JAMES H.,TRAVERS, RICHARD J.,SHENOI, RAJESH,KALATHOTTUKAREN, MANU THOMAS
申请号：
CA2949868
公开号：
CA2949868A1
申请日:
2015.05.29
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Provided herein are polymers and methods for their use in binding a phosphate containing biological macromolecules. Specifically, the methods and uses provided herein may be used to inhibit thrombin binding to polyphosphate or as an antithrombotic agent for the treatment of stroke, acute coronary syndrome, pulmonary embolism, atrial fibrillation, venous and arterial thromboembolism, disseminated intravascular coagulation (DIC), deep-vein thrombosis (DVT), peripheral artery disease, trauma-induced coagulopathy, extracorporeal circulation, cancer-associated thrombosis, sepsis, septic shock, Systemic Inflammatory Response Syndrome (SIRS), or inflammation.
