Conformationally stabilized HIV envelope immunogens

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专利权人:

Peter Kwong

发明人:

Peter Kwong,John Mascola,Gary Nabel,Richard Wyatt,Barna Dey,Ling Xu,Tongqing Zhou,Joseph Sodroski,Wen Yuan,Shi-Hua Xiang

申请号：

US13585700

公开号：

US08715686B2

申请日:

2012.08.14

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a subject.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/