In comparison with pH1.2 or pH6.8 the active ingredient which possesses high liquation speed in pH4 is contained, pH non being the controlled release characteristic formulation which depend it is discharged is controlled, the controlled release characteristic formulation which features that (-) the -2- [the 4- [the 2- [[(1S and 2R) -2- hydroxy -2- (4- hydroxy phenyl) -1- methyl ethyl] amino] ethyl] -2,5- dimethyl phenoxy] ethyl acetate hydrochloride and it contains with the pH non dependant gel formation macromolecule as a active ingredient, substantially does not contain the pH conditioner other than the pH non dependant gel formation macromolecule. The controlled release characteristic formulation of this invention to show pH non depend liquation characteristic in the pH1.2 - 6.8 ranges, because furthermore extending to long haul, it shows fixed liquation ratio, it is useful as the pollakiuria urine incontinence remedy medicine which possesses the persistent effect.pH1.2またはpH6.8に比べてpH4において高い溶出速度を有する有効成分を含有する、pH非依存的に放出制御された徐放性製剤であって、有効成分として(-)-2-[4-[2-[[(1S,2R)-2-ヒドロキシ-2-(4-ヒドロキシフェニル)-1-メチルエチル]アミノ]エチル]-2,5-ジメチルフェノキシ]酢酸エチル塩酸塩とpH非依存性ゲル形成高分子とを含有し、実質的にpH非依存性ゲル形成高分子以外のpH調整剤を含有しないことを特徴とする徐放性製剤。本発明の徐放性製剤は、pH1.2~6.8の範囲においてpH非依存的な溶出性を示し、さらには長時間に亘って一定の溶出率を示すので、持続性効果を有する頻尿・尿失禁治療剤として有用である。
