An auto-occlusion safety device is provided for use in preventing rupture of infusion components during rapid infusion procedures. An occlusion valve is disclosed having a threshold pressure that is less than a rupture tolerance of the infusion system components. As the fluid pressure of the infusion system increases beyond the threshold pressure of the occlusion valve, the occlusion valve is automatically activated thereby occluding fluid flow upstream from a vulnerable infusion component. An accumulator is further disclosed for use in combination with the safety device to compensate for time delays in full activation of the occlusion valve.
