A transdermal permeant administration system for administration of at least one permeant within a tissue membrane of a subject, comprising: i) a disposable substrate (40) defining a poration area (46) and having an upper surface of substrate (42), a lower substrate surface (44), a conduit (56) extending between the upper substrate surface (42) and the lower substrate surface (44), and at least one channel (60) in fluid communication with the conduit (56), said channel forming within the area of poration on the upper surface of the substrate； ii) a first removable coating (110) having an upper surface (112) and an opposite lower surface (114), wherein at least a part of the lower surface of the first removable coating is connected to the upper substrate surface； and iii) a patch (100) that can be selectively removed from the upper surface of the first removable liner comprising: a) a support layer (102) having an upper surface and an opposite lower surface, a first part being mounted ( 107) of the support layer detachably on the upper surface of the first removable coating in spaced alignment with the substrate poration area, and a second part (108) of the support layer that is folded in a folded position, wherein the lower surface of the second part of the support layer faces opposite the upper substrate surface of the substrate； and b) a reservoir (104) which has a portion of the lower surface of the support layer mounted thereon and is capable of releasing at least one permeant.Un sistema de administración transdérmico de permeante para administración de al menos un permeante dentro de una membrana tisular de un sujeto, que comprende: i) un sustrato desechable (40) que define un área de poración (46) y que tiene una superficie superior de sustrato (42), una superficie inferior de sustrato (44), un conducto (56) que se extiende entre la superficie superior de sustrato (42) y la superficie inferior de sustrato (44), y al menos un canal (60) en comunicación fluida co
