Paul R. Morris;Nathan Kast;Lloyd Wolfinbarger;Thomas H. Temple
发明人:
Paul R. Morris,Nathan Kast,Thomas H. Temple,Lloyd Wolfinbarger
申请号：
US14369942
公开号：
US20140341871A1
申请日:
2012.12.28
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A process for the preparation of a tissue matrix suitable for regenerative repair of tissues, including contacting an isolated connective tissue with an amount of detergent and an amount of disinfectant to significantly reduce at least one of lipids, phospholipids, nucleic acids, major histocompatibility (MHC) antigens, contaminating microorganisms, and endotoxins. The process further provides for less significant reduction in proteoglycan content while retaining the overall structure of the tissue matrix produced. Processing may further include micronizing the tissue matrix. Also, a tissue matrix having a scaffold portion and non-structural portion, collectively structured to promote cellular infiltration, attachment, and proliferation. The tissue matrix may be in the form of a sheet, thick sheet, or micronized. Also, kits including a prepared tissue matrix for use in regenerative repair, and kits for preparing a tissue matrix.
