Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to heavy and/or light chain of antibodies, or fragments thereof specific for dendritic cells (DCs) are described herein. Included herein are immunostimulatory compositions (HCV vaccines, HCV antigen presenting dendritic cells, etc.) and methods for increasing effectiveness of HCV antigen presentation by an antigen presenting cell, for a treatment, a prophylaxis or a combination thereof against hepatitis C in a human subject, and methods of providing immunostimulation by activation of one or more dendritic cells, methods to treat or prevent hepatitis C.本文描述一種組合物,其包含對應於或源於C型肝炎病毒(HCV)蛋白質或其片段之病毒抗原及抗原肽,融合至對樹突狀細胞(DC)具有特異性之抗體或其片段之重鏈及/或輕鏈。本文包括免疫刺激組合物(HCV疫苗、HCV抗原呈現樹突狀細胞等),及增強抗原呈現細胞之HCV抗原呈現有效性的方法,抗人類個體之C型肝炎之治療、預防或其組合的方法,及藉由活化一或多個樹突狀細胞來提供免疫刺激之方法,治療或預防C型肝炎之方法。
