#$%^&*AU2017261572A120171207.pdf#####RNA INTERFERENCE MEDIATED INHIBITION OF ISOCITRATE DEHYDROGENASE (IDH1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) ABSTRACT The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of IDH 1 and mutant IDH 1 gene expression and/or activity, and/or modulate an IDHI or mutant IDHI gene expression pathway. Specifically, the invention relates to doublestranded nucleic acid molecules, including small nucleic acid molecules such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, that are capable of mediating or that mediate RNA interference (RNAi) against IDH 1 or mutant IDH 1 gene expression.
