Use of bone marrow cells for long-term culture of islet cells

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专利权人:

ロジャー・ウィリアムズ・ホスピタル

发明人:

ルオ， ルガング,ルオ, ルガング

申请号：

JP2009538403

公开号：

JP5474559B2

申请日:

2007.11.20

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

Bone marrow cells have been demonstrated to be useful in the maintenance of pancreatic islet &bgr； cell viability, structure, and/or function in culture for a sustained period. Bone marrow cells were also found to promote &bgr； cell growth while reducing inflammatory cytokine release and reduce apoptosis. Moreover, islet cells co-cultured with bone marrow cells were shown to retain insulin response function and to function in an islet cell transplant in a mouse model of diabetes to restore normal insulin secretion. Cord blood cells and isolated peripheral CD34+ blood cells were unable to support &bgr； islet cell growth or increase survival.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/