Agis Kydonieus,Michael E. Kafrissen,Katie Macfarlane
申请号：
US15574698
公开号：
US20180125860A1
申请日:
2016.05.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compositions and methods for the delivery of progestin hormones that have binding affinity to the Sex Hormone Binding Globulin (SHBG) are disclosed. The compositions combine such progestins with non-progestin SHBG ligands to displace at least part of the progestin from SHBG in the blood plasma, thereby increasing its bioavailability. Also disclosed are methods to modulate progestin and estrogen levels in the blood through the use of SHBG binding and displacement, to optimize the effectiveness of formulations for contraception and minimize the side effects and adverse events.
