The present invention features methods, compositions, and kits for the treatment of all forms of emotional and painful symptoms related to the menstrual cycle, including symptoms characteristic of menstrual cycle-related disorders, such as premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS), menopause, perimenopause, and sub-diagnostic emotional, psychological, cognitive, spiritual, and/or physical symptoms of the menstrual cycle.