#$%^&*AU2017203769A120170622. Pdf#####ABSTRACT compositions and method are provided for replacing and regenerating inner ear hair cells. The composition includes that the amount of activating agent can effectively reduce 1 gene expressions of HES to inner ear tissue. The activating agent can be encapsulated in Biodegradable nanometer particle with short interfering ribonucleic acid (siRNA) molecule. This method is related to applying solution to inner ear, can effectively reduce 1 gene expressions of HES in the amount that wherein solution includes activating agent.