DE SMEDT, Thibaut,REITH, Walter,MARTI LINDEZ, Adria-Arnau
申请号：
AU2019211067
公开号：
AU2019211067A1
申请日:
2019.01.24
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention concerns a method for treating cancer, including haematological and solid tumors. In an embodiment, the method comprises impairing arginase activity and/or expression in immune cells, in particular T cells of a patient suffering from cancer. Arginase expression may be impaired by mutation (including deletion or truncation) of the arginase encoding gene, by RNA interference or by administration of an arginase inhibitor. In a preferred embodiment, the T cells are modified in the frame of CAR (Chimeric Antigen Receptor) therapy. The invention also provides a method of treatment combining impaired arginase activity with antibody-mediated blockage of negative immune checkpoint regulators (PDL1-PD1 and B7-CTLA4 inhibitory pathways).
