HARMS, Brian,KOHLI, Neeraj,LUGOVSKOY, Alexey,GEDDIE, Melissa,KRAULAND, Eric Mark,ROACH, William George,SU, Stephen,ABU-YOUSIF, Adnan
申请号：
HK16108077.1
公开号：
HK1220465A
申请日:
2016.07.11
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
Provided herein are tandem Fcs and tandem Fc antibodies (“TFcAs”), e.g., tandem Fc bispecific antibodies (“TFcBAs”), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs bind to the cell surface receptors c-Met and EpCam and inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.
