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RADIO-IMMUNO-MODULATION TREATMENT FOR ADVANCED CANCER AND MONITORING TOLERANCE AND CELLULAR IMMUNE RESPONSE AT THE TUMOR SITE
专利权人:
发明人:
Razvan Diaconescu
申请号:
US14187266
公开号:
US20140187845A1
申请日:
2014.02.22
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A combination therapy for treating advanced cancer, comprises, first, performing targeted low dose radiation therapy on a recipient tumoral site to generate an inflammation zone and an immuno-stimulant effect, including release of cytokines and chemokines. Secondly, hematopoietic cells from a suitable donor are administered intravenously in order to initiate an allogeneic reaction. These cells could be collected either as PBMC from an adult donor, or from an UCB donation. The post-radiotherapy inflammation zone will attract the newly injected donor cells to the tumor bed, triggering an immunological cancer cell rejection. The cellular response in the recipient is monitored and post-treatment evaluation for recipients side effects is also provided.
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