使用具有複合狀態之細胞混合物之誘導免疫耐受之抗體、及被誘導之淋巴球、以及使用被誘導之淋巴球之細胞治療劑及治療法农业专利-农业学术服务平台

发明人:: UCHIDA, KOICHIRO,内田浩一郎,内田浩一郎,TAKEDA, KAZUYOSHI,竹田和由,竹田和由,OKUMURA, KO,奥村康,奥村康

摘要：: The present invention provides a pharmaceutical composition for antigen-specific immune tolerance or immunosuppression. The invention provides a pharmaceutical composition comprising CD4 positive disabling T cells and CD8 positive disabling T cells. In some embodiments, the disabled T cells are induced by antibodies that can inhibit the interaction of CD80 and / or CD86 with CD28. In a specific embodiment, the pharmaceutical composition may further contain control T cells (for example, FOXP3 positive CD4 positive CD25 positive T cells).本發明提供一種用於抗原特異性之免疫耐受或免疫抑制之醫藥組合物。本發明提供一種包含CD4陽性失能T細胞與CD8陽性失能T細胞之醫藥組合物。於若干實施形態中，失能T細胞係藉由可抑制CD80及/或CD86與CD28之相互作用之抗體所誘導。於特定之實施形態中，醫藥組合物可進而包含控制性T細胞(例如，FOXP3陽性CD4陽性CD25陽性T細胞)。