Birgit SCHOEBERL,Brian HARMS,Francis David GIBBONS,Jonathan Basil FITZGERALD,Matthew David ONSUM,Ulrik NIELSEN,William KUBASEK
申请号：
US15384664
公开号：
US20170307631A1
申请日:
2016.12.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network Activation State (NAS) or a Network Inhibition State (NIS) for the cells using a computational model of the cellular network. The response of the cells to treatment is then predicted based on the NAS or NIS value that has been computed. The invention also comprises predictive methods for cellular responsiveness in which computation of a NAS or NIS value for the cells (e.g., tumor cells) is combined with use of a statistical classification algorithm. Biomarkers for predicting responsiveness to treatment with a therapeutic agent that targets a component within the ErbB signaling pathway are also provided.
