The present invention belongs to the technical field of chemical drug and crystalline process, and more particularly, to a crystalline form B of pyrroloquinoline quinone and a process for producing the same, and the present invention relates to powder X-ray diffraction analysis, thermogravimetric analysis, differential scanning calorimetry analysis, etc. The B crystal form of pyrroloquinoline quinone is characterized by high degree of crystallinity, low water absorbability and regular crystal form as characterized by the means, and it is possible to process the drug and to treat the physical and chemical performance. It is advantageous for improvement and improves the drug likeness. The process for preparing the B crystalline form of pyrroloquinoline quinone provided by the present invention is simple, easy to control and reproducible.本発明は、化学薬物および結晶形プロセスの技術分野に属し、特にピロロキノリンキノンのB結晶形およびその製造方法に関し、本発明は粉末X線回折分析、熱重量分析、示差走査熱量測定分析などの手段によって全面的に特徴付けたところ、ピロロキノリンキノンのB結晶形は、結晶化度が高く、吸水性が低く、かつ規則的な結晶形態になれ、薬物のプロセス処理および物理・化学的性能の改善に有利で、薬らしさを向上させる。本発明によって提供されるピロロキノリンキノンのB結晶形の製造方法は簡単で、制御しやすく、再現性が良い。
