The radiopharmaceutical is efficiently synthesized under the protein concentration condition that increases the specific radioactivity while ensuring the target radioactivity. In the reaction between the biomolecule and the radiopharmaceutical precursor, the amount of the component contained in the reaction solution in the reaction process that is reacted with the radiopharmaceutical precursor before the reaction at the specified biomolecule concentration is measured, and the reaction is performed from the obtained component amount information. Calculate the rate constant, calculate the reaction rate constant when the biomolecule concentration is changed, predict the reaction time, specific activity, and target activity at each biomolecule concentration. Synthesize under reaction conditions that give the highest specific activity.目的物の放射能量を確保しながら、比放射能が高くなるタンパク質濃度条件で放射性薬剤を効率的に合成する。生体分子と放射性薬剤前駆体の反応において、反応前の放射性薬剤前駆体と所定の生体分子濃度で反応させた反応過程の反応液に含まれる成分量を測定し、得られた成分量情報から反応速度定数を算出し、生体分子濃度を変えたときの反応速度定数を算出し、各生体分子濃度における反応時間、比放射能、目的物の放射能量を予測し、合成要件を満たす反応条件の中で最も比放射能が高くなる反応条件で合成する。
