Chan, Peter Wing Yiu,Ng, Gordon Yiu Kon,Wickman, Grant Raymond
申请号：
AU2014348552
公开号：
AU2014348552A1
申请日:
2014.11.13
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Provided herein are monovalent antigen-binding constructs targeting EGFR and/or HER2. The monovalent antigen-binding constructs can include at least one antigen-binding polypeptide comprising a heavy chain variable domain, wherein the antigen-bind polypeptide specifically binds EGFR and/or HER2； and a heterodimeric Fc domain, the Fc domain comprising at least two CH3 domains, wherein the Fc domain is coupled, with or without a linker, to the antigen-binding polypeptide. Also provided are methods of making the constructs and methods of using the constructs.
