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abuse resistant formulations
专利权人:
Cima Labs Inc.
发明人:
HAMED, Ehab,KRALING, Carrie
申请号:
ES11705797
公开号:
ES2628886T3
申请日:
2011.02.23
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
An oral dosage form (also called "pharmaceutical form", "presentation form" or "administration medium") of sustained release, comprising: a matrix, so that the matrix comprises a first viscosity modifier in an amount of between 1% and 10% by weight of the dosage form; and coated granules (or 'coated granules'), comprising: a granule, containing hydrocodone or a salt form thereof in an amount of between 0.1% and 90% by weight of the granule, a first former powerful films in an amount of between 1% and 90% by weight of the granule, and a second viscosity modifier in an amount of between 1% and 90% by weight of the granule, so that the granule does not contain any grease / wax, a coating on the granule, so that the coating is present in an amount of between 20% and 80% by weight of the coated granule, so that the coating comprises a second powerful film former in an amount between 10% and 50% by weight of the coated granule, and a grease / wax in an amount of between 10% and 25% by weight of the coated granule, so that the first and second powerful film former are independently selected from a group that is composed ne of: ethyl cellulose; ammonium methacrylate copolymer, type B; ammonium methacrylate copolymer, type A; aminomethacrylate copolymer; a dispersion of copolymers of ethyl acrylate and methyl methacrylate; copolymer of methacrylic acid, type A; copolymer of methacrylic acid, type B; and shellac, and so that the first and second viscosity modifiers are independently selected from a group consisting of: sodium alginate, hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone , crosslinked polyacrylic acid, gelatin, pectins, gums, polyethylene oxides, Konjac flour, carrageenan, xanthan gum or mixtures of these compounds.Una forma de dosificación oral (también llamada 'forma farmacéutica', 'forma de presentación' o 'medio de administración') de liber
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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