POPOV ALEXEY,포포브, 알렉세이,ENLOW ELIZABETH M.,엔로우, 엘리자베스, 엠.,CHEN HONGMING,첸, 홍밍
申请号：
KR1020147033577
公开号：
KR1020150006869A
申请日:
2013.05.03
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.점액 중에서 입자 수송을 보조하는 입자, 조성물 및 방법이 제공된다. 일부 실시양태에서, 조성물 및 방법은 낮은 수용해도를 갖는 약제의 입자와 같은 입자의 표면 코팅물을 개질시키는 것을 포함할 수 있다. 이러한 입자를 포함하는 제약 조성물은 안과용 적용에 적절하고, 눈 앞쪽 및/또는 눈 뒤쪽에 약제를 전달하는데 사용될 수 있다.
