The purpose of this invention is to control the expression of iNOS(inducible nitric oxide), this invention relates to a senseoligonucleotide having a complementary sequence to a single strand RNA(antisense transcript) having a complementary sequence to the mRNA of iNOS gene. Using the senseoligonucleotide of this invention, the expression of iNOS being able to be controlled, so it is useful for treating and preventing the diseases relating to body defence or NO over production, such as cancer, inflammation, endotoxic shock caused by bacteria infection, etc.本發明以調控iNOS(誘導型一氧化氮合成酶;inducible nitric oxide synthase)之表現為目的,係有關具有與iNOS基因之mRNA為互補鹼基序列的單股RNA(反義轉錄物(antisense transcript))之互補序列之正義寡核苷酸(senseoligonucleotide)。使用本發明之正義寡核苷酸,可調控iNOS之表現,而可用於治療及預防與生體防御或NO過剩產生有關之疾病,例如癌或炎症性疾病、因細菌感染等引起之內毒素休克等。無元件符號
