INHIBITEURS DE KINASES TRICYCLIQUES DE MELK ET PROCÉDÉS D'UTILISATION

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专利权人:

Inc.;Dana-Farber Cancer Institute

发明人:

GRAY, Nathanael,ZHANG, Tinghu,HUANG, Hai-tsang,WANG, Yubao,ZHAO, Jean,CHOI, Hwan, Geun

申请号：

EP16759581

公开号：

EP3265093A4

申请日:

2016.03.04

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Provided herein are tricyclic small molecule inhibitors of maternal embryonic leucine zipper kinase (MELK). The compounds are useful for treating cancer and other conditions or diseases associated with aberrant MELK expression. Also provided herein are pharmaceutical compositions comprising a tricyclic compound of the invention and a pharmaceutically acceptable carrier. The invention also provides methods of treating cancers associated with over-expression of MELK.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/